Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer
نویسندگان
چکیده
منابع مشابه
Characterization of fragment E from fibrinogen and cross-linked fibrin.
Fragment E, a terminal plasmin digestion product of fibrinogen or fibrin, contains portions of the alpha, beta, and gamma chains linked by disulfide bonds. In this study, Fragment E from fibrinogen and fully cross-linked fibrin were purified by gel filtration of the soluble fraction from heated plasmin digests of either fibrinogen or fibrin or by step-wise chromatography of terminal plasmin dig...
متن کاملSubunit structure of fragment D from fibrinogen and cross-linked fibrin.
The different species of Fragment D were purified from plasmin digests of either fibrinogen or highly cross-linked fibrin and examined electrophoretically in sodium dodecyl sulfate on polyacrylamide gels before and after reduction by ,&mercaptoethanol. It was found that Fragment D from cross-linked fibrin is approximately twice the size of that from fibrinogen, which indicates that the COOH-ter...
متن کاملRole of fibrin D-dimer testing in emergency medicine.
OBJECTIVES Systemic values of the fibrinolytic plasma marker fibrin D-dimer are raised in a variety of acute clinical conditions. D-dimer values can now be rapidly determined and used to aid diagnosis in emergency medicine. However, despite clinical guidelines, inappropriate and unnecessary measurement of D-dimer values is a significant clinical problem. An understanding of the pathophysiologic...
متن کاملIntracardiac mobile thrombus and D-dimer fragment of fibrin in patients with mitral stenosis.
OBJECTIVE To investigate the relation between intracardiac thrombus and blood coagulability in patients with mitral stenosis. DESIGN Prospective study. Cross sectional echocardiography and plasma concentrations of the D-dimer fragment of fibrin were used concurrently to detect intracardiac thrombus in patients with mitral stenosis. SETTING Department of Medicine, National Cardiovascular Cen...
متن کاملFibrin fragment D-dimer and the risk of future venous thrombosis.
Plasma D-dimer concentration rises more than 100-fold during acute deep vein thrombosis, but there are no prospective data concerning D-dimer as a risk factor for incident venous thrombosis in a general population. Incident venous thrombosis was ascertained in 2 prospective observational studies, the Atherosclerosis Risk in Communities Study and the Cardiovascular Health Study. Of 21 690 partic...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2020
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2020001545